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Model of CXCL12 function(s) in the mPFC. In the postnatal mPFC, CXCL12 is detected around the extracellular surface of layer V pyramidal neurons (shown in green), while its receptors CXCR4 and CXCR7 are present at the axon terminals of PV+ basket interneurons (shown in orange). CXCL12 promotes targeting of PV+ basket interneuron axons, the number of inhibitory perisomatic synapses, and IPSCs onto layer V pyramidal neurons.
