Table 1.

Multivariate Cox proportional hazards model for OS among RAEB patients (N = 336)

Characteristics	Hazard ratio (95% CI)	P
HMA-type decitabine (ref = azacitidine)	0.96 (0.70-1.31)	.78
ESA use pre-HMA (ref = No)	1.05 (0.80-1.37)	.73
Year of MDS diagnosis (ref = 2004-2005)		.96
2006-2007	0.95 (0.66-1.36)
2008	0.96 (0.65-1.40)
Time to first HMA, mo	0.98 (0.96-1.00)	.02
Age group, y (ref = 66-69)		.14
70-74	1.33 (0.92-1.92)
75-79	1.36 (0.94-1.97)
80+	1.58 (1.08-2.30)
Sex (ref = male)	0.95 (0.75-1.21)	.69
Race other than white (ref = white)	0.76 (0.53-1.11)	.16
Hispanic (ref = no)	1.61 (0.90-2.86)	.11
Marital status (ref = married)		.06
Single/Div/Sep/Wid/Unmarried	1.03 (0.78-1.37)
Unknown	0.60 (0.39-0.94)
Elixhauser Comorbidity Index pre-HMA (ref = 0)		.44
1-2	0.81 (0.59-1.12)
>3	0.89 (0.63-1.25)
Disability (ref = not disabled)		.87
Disabled	1.05 (0.62-1.78)
RBC transfusion group (ref = 0)		<.001
1-2	1.76 (1.29-2.41)
≥3	1.95 (1.43-2.65)
Platelet transfusion group (ref = 0)		.01
1-2	1.56 (0.95-2.57)
≥3	1.89 (1.21-2.96)
Adults 25+ y in zip code with ≤ HS education, % (ref ≤ 33%)		.46
33-66	1.07 (0.79-1.44)
≥66	0.83 (0.50-1.37)
Income (ref = <$33 000)		.89
$33 000-40 000	0.92 (0.57-1.48)
$40 000-50 000	0.86 (0.56-1.30)
≥$50 000	0.94 (0.60-1.46)
Metro (ref = metro area)		.30
Nonmetro	1.22 (0.84-1.78)

Div, divorced; ESA, erythropoiesis-stimulating agent; HS, high school; ref, reference value; Sep, separated; Wid, widowed.