Skip to main content
. Author manuscript; available in PMC: 2019 Mar 11.
Published in final edited form as: Amino Acids. 2010 Jul 2;41(4):789–796. doi: 10.1007/s00726-010-0666-4

Figure3: hS100A7 and hS100A15 function through distinct classes of receptors.

Figure3:

A) Frozen sections of inflamed lesional psoriasis were stained for hS100A7 (green) and hS100A15 (red) showing differential upregulation of both S100 proteins. Nuclei were stained with DAPI (blue). Bar size: 50 μm. B) Recombinant hS100A7, hS100A15 were injected intraperitoneally into C57/BL6 wild-type mice alone or premixed in combination. After four hours, cells attracted into the peritoneal fluid were counted and analyzed by flow cytometry using the granulocyte marker Gr-1. (mean value + s.d. from six mice, * P ≤ 0.05). C) hS100A7 mediates leukocyte chemotaxis through RAGE (receptor of advanced glycated end products). This atypical chemotaxis receptor is pertussis toxin-insensitive, which helps distinguish ligand activity through classical chemokine receptors. hS100A15 chemotactic activity is Gi-protein-dependent, however the receptor has to be specified.