. 2019 Feb 28;4(2):4405–4416. doi: 10.1021/acsomega.8b03582

Table 1. Sequence Conservation of Reported Integrin-, Heparin-, and Fibronectin-Binding Motifs and Sequences Encoded by Exons 5 and 6 of Ambn across 47 Different Species from the Classes of Ray-Finned Fishes, Lobe-Finned Fishes, Amphibians, Reptiles, and Mammals^a.

reported motifs	sequence	location	species with identical motif (#)	species with identical motif (%)	average conservation score
heparin-binding motifs	HSLSRGPMAHNK	exon 10	1/47	2.1	0.22
	VTKG	exon 13	4/47	8.5	–0.28
	KVHQPQVHNAWR	exon 13	2/47	4.3	0.30
fibronectin-binding motif	VPIMDFADPQFPT	exon 7	2/47	4.3	0.94
integrin-binding motif	DGEA	exon 13	3/47	6.4	2.66
N/A	sequence encoded by exon 5	exon 5	N/A	N/A	–0.58
N/A	sequence encoded by exon 6	exon 6	N/A	N/A	0.34

The conservation scores were calculated by ConSurf. The GenBank accession numbers are provided in Table S1. “N/A” is used in the “species with identical motif” columns for exons 5 and 6 because no defined motifs have been reported for these sequences. Average conservation score and “species with identical motif” are two independent values. See the Experimental Section for the definition of Average conservation score. Note that more negative numbers indicate higher conservation.

Table 1. Sequence Conservation of Reported Integrin-, Heparin-, and Fibronectin-Binding Motifs and Sequences Encoded by Exons 5 and 6 of Ambn across 47 Different Species from the Classes of Ray-Finned Fishes, Lobe-Finned Fishes, Amphibians, Reptiles, and Mammalsa.

Table 1. Sequence Conservation of Reported Integrin-, Heparin-, and Fibronectin-Binding Motifs and Sequences Encoded by Exons 5 and 6 of Ambn across 47 Different Species from the Classes of Ray-Finned Fishes, Lobe-Finned Fishes, Amphibians, Reptiles, and Mammals^a.