Figure 3B.

Dependence of the values of R on time for three systems with different affinities (A) and different values of $k_{\text{on}}(s^{-1})$ and $k_{\text{off}}(s^{-1})$. Panel models: (g) kpr with stabilizing activation chain; (h) kpr with limited and sustained signaling; (i) kpr with negative feedback and limited signaling; (j) kpr with stabilizing activation chain and limited signaling; (k) kpr with stabilizing activation chain and sustained signaling; (l) kpr with limited signaling coupled to an incoherent feed-forward loop. Other conditions as in Figures 2A, 3A.