Table 2. The distribution of reverse transcriptase (RT) mutations and HBsAg vaccine escape mutations among the study population.
| Sample ID | Age | Gender | Year of Dx1 | Sub-genotype | Rx status2 | Mutations RT3 | Escape mutations |
|---|---|---|---|---|---|---|---|
| 22 | 38 | Male | 2009 | D1 | Naïve | N53S, F122I, H124D, Y135S, H216L, L217F | – |
| 39 | 35 | Male | 2009 | D1 | Unknown | Y135S, H216L, L217F | – |
| 84 | 35 | Male | Unknown | D1 | Unknown | F122I, H124Y, Y135S, H216L, L217F | – |
| 97 | 36 | Male | 1995 | D1 | Naïve | R110G, Y135S, H216L | – |
| 23 | 68 | Male | 2009 | D1 | Unknown | F122I, H124Y, Y135S, H216L | – |
| 66 | 38 | Male | 2004 | D1 | Unknown | H124Y, Y135S, I163V, H216I, L217F | – |
| 85 | 33 | Female | 2004 | D1 | Naïve | S119P, H124Y, Y135S, H216L | – |
| 99 | 33 | Male | 2007 | D1 | Experienced (Lamivudine) | F122I, H124Y, Y135S, L217F | – |
| 4 | 30 | Male | 2006 | D1 | Naïve | L91I, H124Y, N131D, Y135S, H216L, L217F | – |
| 24 | 22 | Female | 2009 | D1 | Experienced (Lamivudine) | Y135S, H216I, L217F | – |
| 45 | 38 | Female | 1998 | D1 | Experienced (Lamivudine) | H124Y, Y135S, Q215H, H216L | – |
| 101 | 30 | Male | 2010 | D1 | Unknown | F122I, H124Y, Y135S, H216L, L217F | – |
| 2 | 60 | Male | 2009 | D1 | Experienced (Lamivudine) | Y135S, H216L, L217F | R122K |
| 46 | 35 | Female | 2000 | D1 | Experienced (Lamivudine) | H124Y, Y135S, Q215H, H216F, L217W | – |
| 57 | 39 | Female | 2010 | D1 | Unknown | A38E, Y54H, M129L, Y135S, V173L, H216L | – |
| 87 | 30 | Male | 2011 | D1 | Unknown | K32M, Y135S, S213T, H216I | – |
| 106 | 47 | Male | 2011 | D1 | Unknown | F122I, H124Y, Y135S, H216L | – |
| 6 | 13 | Male | 2009 | D1 | Experienced (Lamivudine) | H124Y, Y135S, Q149K, H216L | – |
| 49 | 32 | Female | 2008 | D1 | Unknown | S85A, Y135S, N139D, L199V, H216I, L217W | L109R |
| 76 | 51 | Female | 2009 | D1 | Naïve | L91I, H124D, Y135S, K212N, H216P | S143L |
| 81 | 38 | Male | 1998 | D1 | Experienced (Lamivudine) | S78T, F122I, H124Y, Y135S, H216I | – |
| 83 | 51 | Male | 2000 | D1 | Unknown | A38E, R110G, F122I, H124Y, Y135S, Q149K, S176T, S185I, H197P, C198R, S202I, V208I, A211G, K212G, S213Q, V214Y, Q215L, H216L, L217F | – |
| 5 | 11 | Male | 2009 | D1 | Experienced (Lamivudine) | Y135S, H216L, L217F | – |
| 34 | 26 | Male | 2008 | D1 | Unknown | F122I, H124Y, Y135S, H216L | – |
| 52 | 25 | Male | 2009 | D1 | Naïve | H124Y, Y135S, H216P | – |
| 70 | 44 | Male | 2011 | D1 | Naïve | Y54G, N76D, Y135S, Y141F, H216I, L217F | M133L |
| 89 | 24 | Male | 2009 | D1 | Unknown | Y54H, Y135S, H216L | D144E |
| 105 | 48 | Female | 2011 | D1 | Naïve | H124Y, T128P, Y135S, L145M, H216P | – |
| 8 | 60 | Male | 1984 | D1 | Experienced (Lamivudine) | A38E, Y54H, H124Y, M129L, Y135S, V173L, L180M, M204V, H216L | – |
| 35 | 29 | Male | 2009 | D1 | Unknown | S109P, Y135S, H216L, L217F | – |
| 56 | 36 | Male | 2010 | D1 | Unknown | T37A, F122L, N123D, Y135S, H216L | – |
| 77 | 65 | Male | 2011 | D1 | Naïve | H124Y, Y135S, G152K, K154N, I187L, H216P, L217F | – |
| 103 | 23 | Female | 2011 | D1 | Naïve | N53K, F122I, H124Y, Y135S, H216L | – |
| 63 | 77 | Male | 2004 | D1 | Unknown | H124Y, Y135S, Q215H, H216T, L217F | R122K |
| 38 | 34 | Female | 2007 | D1 | Unknown | F122I, H124Y, Y135S, H216I, L217W | – |
| 58 | 65 | Female | 2006 | D1 | Unknown | V27A, A38E, S117N, N118D, H124D, Y135S, S137T, L180M, M204V, H216L | R122K, Q129R |
| 104 | 37 | Male | 2007 | D1 | Experienced (Lamivudine) | A38E, H124Y, Y135S, L180M, T184A, M204V, H216I | – |
Notes:
RT mutation conferring possible or confirmed resistance to RT inhibitors are highlighted in bold.
Dx, diagnosis.
Rx, treatment.
RT, reverse transcriptase.