TABLE 4.

Summary of Effects Statin Rate Differences on Outcomes by Patient Complexity

	Lower Intensity Statins			High-intensity Statins
		Estimated Effects Associated With Higher Rate†			Estimated Effects Associated With Higher Rate†
Complexity	Rate Range*	Benefit Increase‡	Risk Increase§	Rate Range*	Benefit Increase‡	Risk Increase§
All patients	43–57	Yes	Yes	9–16	Yes	Yes
Noncomplex	47–64	No	No	7–24	Yes	No
Heart failure	41–52	Yes	No	6–16	Yes	Yes
CKD	41–52	No	Yes	6–17	Yes	Yes
Diabetes	44–55	Yes	No	7–18	Yes	Yes

^*Quintile range of statin utilization rates across local areas for respective complexity and age group.

^†Relative to no statin based on statin rates in 2008–2009.

^‡“Yes” if statistically significant increase in 1-year survival or 1-year cardiovascular event-free survival rates is associated with a statin rate increase.

^§“yes” if statistically significant increase in 1-year muscle-related adverse events, renal-related adverse events or hepatic-related adverse event rates is associated with a statin rate increase.

CKD indicates chronic kidney disease.