. Author manuscript; available in PMC: 2019 Mar 11.

Published in final edited form as: Int Rev Psychiatry. 2017 Dec 5;29(6):618–627. doi: 10.1080/09540261.2017.1398139

Table 1.

Summary of D₂-like receptor PET findings in ICB

First Author	Last Author	Publication Year	Radioligand	ICB Type	Method	Significant ROIs
Evans	Piccini	2006	[¹¹C]raclopride	Dopamine Dysregulation Syndrome	Acute (levodeopa challenge)	Ventral striatum (⁺)
					Baseline	None
					Behavioral correlation (disease severity^a)	Ventral striatum (pos.)
Steeves	Strafella	2009	[¹¹C]raclopride	Pathological gambling	Acute (gambling task)	Ventral striatum (⁺)
Steeves	Strafella	2009	[¹¹C]raclopride	Pathological gambling	Baseline (control task)	Ventral striatum (^ICB+<ICB-)
O’Sullivan	Piccini	2011	[¹¹C]raclopride	General ICB	Acute (levodopa + neutral cues)	None
					Acute (levodopa + reward-related cues)	Ventral striatum (⁺)
					Baseline	None
Ray	Strafella	2012	[¹¹C]FLB-457	Pathological gambling	Acute (gambling task)	Midbrain (⁻)
					Baseline (control task)	ACC (^ICB+>ICB-)
					Behavioral correlation (state impulsivity^b)	Midbrain (pos.) ACC (pos.)
Payer	Boileau	2015	[¹¹C]-(⁺)-PHNO	General ICB	Baseline	Ventral striatum (^ICB+<ICB-) Dorsal striatum (^ICB+>ICB-)
Payer	Boileau	2015	[¹¹C]-(⁺)-PHNO	General ICB	Behavioral correlation (ICB severity^a,b)	Ventral striatum (neg.)

(ICB+>ICB-): indicates baseline D2/3 BPnd increase in ICB+ compared to ICB- subjects

(ICB+<ICB-): indicates baseline D2/3 BPnd decrease in ICB+ compared to ICB- subjects

(+): indicates increased dopamine release in ICB+ subjects

(−): indicates decreased dopamine release in ICB+ subjects

(pos.): indicates positive correlation

(neg.): indicates negative correlation

ACC: anterior cingulate cortex

^a:

“wanting” drug (Drug Effects Questionnaire)

^b:

Barratt Impulsivity Scale-11