. Author manuscript; available in PMC: 2019 Mar 11.

Published in final edited form as: Int Rev Psychiatry. 2017 Dec 5;29(6):618–627. doi: 10.1080/09540261.2017.1398139

Table 2.

Summary of DAT SPECT findings in ICB

Authors	Publication Year	Radioligand	ICB Type	Method	Significant ROIs
Cilia et al.	2010	[¹²³I]FP-CIT	Pathological gambling	Baseline	Ventral striatum (ICB+<ICB-)
Voon et al.	2014	[¹²³I]FP-CIT	General ICB	Baseline	Ventral striatum (ICB+<ICB-)
Vriend et al.	2014	[¹²³I]FP-CIT	General ICB	Baseline (longitudinal)	Ventral striatum (ICB+<ICB-) Ventral striatum (ICB+<ICB-)
Smith et al.	2016	DaTSCAN™ [¹²³I]β-CIT	General ICB	Baseline (longitudinal)	Right caudate^a (ICB+<ICB-) Right putamen^b (ICB+<ICB-) Total striatum^a,b (ICB+<ICB-)

(ICB+>ICB-): indicates baseline DAT binding increase in ICB+ compared to ICB- subjects

(ICB+<ICB-): indicates baseline DAT binding decrease in ICB+ compared to ICB- subjects

^a:

over the first first year

at any post-baseline visit