While adjusting for SES and parental history of SUD, we found that those with persistent BPD had the highest risk for SUD and cigarette smoking compared to those with non-persistent BPD and controls (SUD: Non-persisdent vs. controls: HR: 1.6; 95% CI: 0.7, 3.5; p = 0.25; presisdent vs. controls: HR: 2.5; 95% CI: 1.3, 4.6; p = 0.005; presisdent vs. non-persisdent: HR: 1.5; 95% CI: 0.7, 3.2; p = 0.25; Cigarette Smoking: Non-presistent vs. controls: HR: 2.1; 95% CI: 0.9, 5.3; p = 0.11; Persistent vs. controls: HR: 4.1; 95% CI: 1.9, 8.9; p < 0.001; persistent vs. non-persistent: HR: 2.0; 95% CI: 0.9, 4.9; p = 0.09).