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. Author manuscript; available in PMC: 2019 Mar 11.
Published in final edited form as: J Am Chem Soc. 2018 Oct 19;140(43):13988–14009. doi: 10.1021/jacs.8b05195

Figure 24.

Figure 24.

Catalyst controlled site-divergence. (A) Predictable site-divergent selectivities in natural product artemisinin using Fe(PDP) or Fe(CF3-PDP). (B) Prior to Fe(PDP), site-selective oxidations on artemisinin had only been reported with enzymes. (C) Site-divergence in the cyanthiwigin core. The modest yields for tertiary hydroxylation underscores the importance of finding the “matched” version of the chiral Fe(PDP) catalyst with chiral substrates. Panel A: Reproduced with permission from ref 13. Copyright 2013 ACS.