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Atomistic change of C(sp3)–H to C(sp3)–N and C(sp3)–C impact a molecule’s properties. (A) The first broad-spectrum penicillin derivative (ampicillin) differs from penicillin G by the introduction of a benzylic amine. (B) The introduction of a methyl group, often alpha to heteroatoms, can significantly boost the potency of drug candidates and is referred to as the “magic methyl effect”.
