Fig. 2.

(A and B) Local frustration patterns of EC classes for (A) monomers and (B) homodimers. The ratio of the $g\left(r\right)$ value for each type of contact (green, minimally frustrated; red, highly frustrated; gray, neutral) and the total $g\left(r\right)$ involving all interaction functions is shown. The first shell is defined from 0.5 Å to 1.5 Å with respect to the catalytic residue positions, and the second shell is defined from 2 Å to 3.5 Å.