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(A) CDR vicinity PSH scores across the 137 CST (blue) and human VdH Ig-seq (red) models. The CSTs are underrepresented at higher PSH values. (B) Galiximab (Kyte and Doolittle CDR vicinity PSH score of 167.89) has a large surface-exposed patch of hydrophobicity in its CDRH3 loop. Heavy-and light-chain surfaces outside the CDR vicinity are colored in white.
