Skip to main content
. 2019 Feb 14;116(10):4025–4030. doi: 10.1073/pnas.1810576116

Fig. 4.

Fig. 4.

The (A) CDR vicinity PSH and (B) CDR vicinity PNC metrics for the combined set of 242 CSTs (light blue) and MedImmune case studies (colored by assigned flag). MEDI-578, MEDI-1912, and MEDI-1912STT all have the CDR vicinity PNC value labeled by an asterisk. Amber and red dashed lines delineate the 242 CST guideline thresholds. Case studies with prohibitive developability issues (MEDI-1912, AB001) are red-flagged for the PSH and PNC metrics, respectively. Engineered versions without developability issues (MEDI-1912STT, AB001DDEN) return to the range of values previously seen in CSTs for all metrics. MEDI-578/1912/1912STT are labeled as M-578/1912/1912STT, and AB-001/008/001DDEN are labeled as A-001/008/DDEN for legibility.