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. 2019 Jan 30;116(10):4558–4566. doi: 10.1073/pnas.1815515116

Fig. 2.

Fig. 2.

Inhibition of CXCR4 reduces stromal αSMA+ cells in tumors. (A) αSMA-dsRed mice bearing mammary fat pad windows were implanted with MCa-M3C-CFP breast tumors. Representative time-lapse images from intravital multiphoton microscopy of cancer cells (blue) and αSMA+ cells (red) at days 1, 3, 7, and 13 postimplantation and during treatment of AMD3100 or saline (control). CXCR4 inhibition delays the accumulation of αSMA+ cells at both the center and periphery of the tumors. (Scale bar, 100 μm.) (B) Area fractions and representative histology images of tumor αSMA+ cells show that AMD3100 reduces density of αSMA+ cells in the tumors (*P < 0.05, Student’s t test). (Scale bar, 100 μm.)