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Histopathological analyses of the uteri with PTEN LOF and/or PI3K GOF mutation. Biallelic loss of Pten (A), GOF mutation of PI3K (B), and the combination of loss of Pten and PI3K GOF (C) followed up to 6 mo. Insets (IHC): Epithelial lesions were highlighted by loss of PTEN proteins (A), Cre activation (GFP) (B and C), and phosphorylation of AKT (A–C). (Scale bars: 100 μm.)
