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PGC1A regulates IRS protein expression. Immunoblots of protein from primary hepatocytes treated 15 min with 100 nM insulin. (A) Cells overexpressing vector control (CTL), PGC1A, or PGC1B. (B) Cells from LA/BKO mice. (C) Ratio of p-AKT to t-AKT in cells overexpressing PGC1A or PGC1B (n = 4 ± SEM, performed at least two times).
