Table 1.

Plasma and urine biochemistries in Wnk4 L319F/L321F KI and WT mice

Group	WT (n = 12)	KI (n = 12)
Body weight, g	19.4 ± 1.0	19.9 ± 1.0
Blood pressure, mm Hg	105 ± 2.1/64 ± 1.6	114 ± 3.0*/71 ± 1.9*
Plasma
BUN, mg/dL	26.5 ± 1.7	25.7 ± 1.6
Creatinine, mg/dL	0.25 ± 0.03	0.24 ± 0.03
Na+, mM	151.5 ± 0.56	151.8 ± 0.68
K+, mM	4.37 ± 0.10	4.75 ± 0.10*
Cl−, mM	117.2 ± 0.75	119.3 ± 1.2*
Ca2+, mg/dL	4.92 ± 0.11	4.95 ± 0.10
Mg2+, mg/dL	2.87 ± 0.07	2.88 ± 0.08
Hb, g/dL	13.5 ± 0.16	13.7 ± 0.14
pH	7.36 ± 0.01	7.34 ± 0.01
HCO3−, mM	19.4 ± 0.51	17.6 ± 0.36*
Total CO2, mM	20.1 ± 0.57	18.7 ± 0.38*
Urine
Volume, mL	1.72 ± 0.21	1.52 ± 0.13
Na+ excretion, μmol/h	6.1 ± 0.30	6.3 ± 0.17
K+ excretion, μmol/h	11.2 ± 0.5	10.7 ± 0.3
FENa, %	0.34 ± 0.05	0.38 ± 0.03
FEK, %	32.8 ± 1.4	26.8 ± 1.7*

FE, fractional excretion; KI, knockin. *P < 0.05.