Table 1.
Group | WT (n = 12) | KI (n = 12) |
Body weight, g | 19.4 ± 1.0 | 19.9 ± 1.0 |
Blood pressure, mm Hg | 105 ± 2.1/64 ± 1.6 | 114 ± 3.0*/71 ± 1.9* |
Plasma | ||
BUN, mg/dL | 26.5 ± 1.7 | 25.7 ± 1.6 |
Creatinine, mg/dL | 0.25 ± 0.03 | 0.24 ± 0.03 |
Na+, mM | 151.5 ± 0.56 | 151.8 ± 0.68 |
K+, mM | 4.37 ± 0.10 | 4.75 ± 0.10* |
Cl−, mM | 117.2 ± 0.75 | 119.3 ± 1.2* |
Ca2+, mg/dL | 4.92 ± 0.11 | 4.95 ± 0.10 |
Mg2+, mg/dL | 2.87 ± 0.07 | 2.88 ± 0.08 |
Hb, g/dL | 13.5 ± 0.16 | 13.7 ± 0.14 |
pH | 7.36 ± 0.01 | 7.34 ± 0.01 |
HCO3−, mM | 19.4 ± 0.51 | 17.6 ± 0.36* |
Total CO2, mM | 20.1 ± 0.57 | 18.7 ± 0.38* |
Urine | ||
Volume, mL | 1.72 ± 0.21 | 1.52 ± 0.13 |
Na+ excretion, μmol/h | 6.1 ± 0.30 | 6.3 ± 0.17 |
K+ excretion, μmol/h | 11.2 ± 0.5 | 10.7 ± 0.3 |
FENa, % | 0.34 ± 0.05 | 0.38 ± 0.03 |
FEK, % | 32.8 ± 1.4 | 26.8 ± 1.7* |
FE, fractional excretion; KI, knockin. *P < 0.05.