Fig. 5.

Gene expression modules showing correlations in relation to invasive capacity, sex, O₂ treatment, and disease status (EOPE vs. CTL) as determined by WGCNA. (A) A total of 3,845 genes from combined CTL TB and EOPE TB samples identified five coexpressed gene modules. Out of the five modules, two (A1 and A3) showed a significant correlation with invasion and O₂ levels, but none correlated with disease status. (B) WGCNA analysis of a total of 3,682 genes for CTL TB. Ten coexpressed gene modules were identified. (C) WGCNA analysis of a total of 3,789 genes for EOPE TB. Four coexpressed gene modules were identified. Each module name is shown on the left, and each column represents the correlation value with the corresponding adjusted P value in parentheses. Positive correlations are shown in red, and negative correlations are shown in blue, with white signifying no correlation.