Table 1.
Samples used in the study
| CTL or EOPE | Sample ID | Sex | Gestational age, wk | Clinical condition* | Mode of delivery† | Betamethasone (B), (× no. of injections) | Microarray analysis of cells grown in 4%, 20% O2 |
| CTL | 1 | M | 39 3/7 | Normal | SVD | No | No, no |
| CTL | 2 | F | 37 | Normal | CD | No | Yes, yes |
| CTL | 3 | M | 39 2/7 | Normal | SVD | No | Yes, yes |
| CTL | 4 | M | 40 | Normal | CD (breech) | No | Yes, yes |
| CTL | 5 | F | 39 3/7 | Normal | (Repeat) CD | No | Yes, yes |
| CTL | 6 | M | 40 | Normal | SVD | No | Yes, yes |
| CTL | 7 | M | 34 | Preterm Premature Rupture of Membranes (PPROM) | SVD | B (× 2) | Yes, yes |
| CTL | 8 | F | 33 | PPROM | SVD | no | Yes, yes |
| CTL | 9 | F | 39 | Normal | CD | no | Yes, yes |
| CTL | 10 | F | 39 1/7 | Normal | CD | no | Yes, yes |
| EOPE | A | F | 30 5/7 | HELLP syndrome | CD | B (× 2) | Yes, yes |
| EOPE | B | M | 29 5/7 | Severe PE | CD | No, due to emergent delivery | Yes, yes |
| EOPE | C | M | 32 3/7 | Severe PE | CD | B (× 2) | Yes, yes |
| EOPE | D | M | 32 4/7 | Severe PE | CD | B (× 2) | Yes, yes |
| EOPE | E | M | 34 1/7 | HELLP syndrome | CD | No, due to age > 34 wk | No, no |
| EOPE | F | M | 32 6/7 | Severe PE, IUGR | CD | B (× 2) | Yes, yes |
| EOPE | G | M | 30 | Severe PE superimposed on maternal hypertension | (Repeat) CD | B (× 2) | Yes, yes |
| EOPE | H | M | 31 | Severe PE | (Repeat) CD | B (× 3) | Yes, yes |
| EOPE | I | M | 29 | Severe PE, dichorionic/diammniotic twins | (Repeat) CD | B (× 2) | Yes, yes |
| EOPE | J | M | 29 | Severe PE, dichorionic/diammniotic twins | (Repeat) CD | B (× 2) | Yes, yes |
| EOPE | K | M | 27 3/7 | Severe PE | CD | B (× 2) | Yes, yes |
| EOPE | L | M | 26 6/7 | Severe PE | CD (breech) | B (× 2) | No, yes |
| EOPE | M | M | 33 5/7 | Severe PE | CD (breech) | B (× 2) | Yes, yes |
| EOPE | N | M | 28 5/7 | Severe PE | CD | B (× 2) | Yes, yes |
| EOPE | O | M | 28 5/7 | Severe PE | CD | B (× 2) | Yes, yes |
| EOPE | P | F | 31 5/7 | Severe PE, IUGR | CD | B (× 1) | Yes, yes |
| EOPE | Q | F | 27 | Severe PE | CD | B (× 2) | No, no |
| EOPE | R | F | 34 1/7 | Severe PE | SVD | B (× 2) | No, no |
| EOPE | S | F | 32 6/7 | HELLP syndrome | SVD | B (× 4) | No, no |
Patient information for UC samples collected from CTLs (1 to 10) and from infants whose mothers suffered EOPE (A to S). Note that the majority of EOPE lines were derived from infants after Cesarian delivery. Half of CTL lines and two EOPE lines were generated following spontaneous vaginal delivery of the infants. All mothers in the EOPE group, with the exception of B and E, received from one to four injections of betamethasone before delivery. Of the CTLs, only the mother of infant 7 received betamethasone.
*
HELLP, haemolysis, elevated liver enzymes and low platelets; IUGR, intrauterine growth restriction; PPROM, preterm premature rupture of membranes.
†
CD, Cesarean delivery; SVD, spontaneous vaginal delivery.