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. 2018 Jun 26;111(3):292–300. doi: 10.1093/jnci/djy107

Figure 3.

Figure 3.

The effect of fibrinogen-like protein 2 (FGL2) overexpression on malignant progression in vivo. A) Kaplan-Meier analysis demonstrating symptom-free survival in Ntv-a mice from the replication-competent ASLV long terminal repeat with a splice (RCAS) platelet-derived growth factor subunit B (PDGFB), RCAS-PDGFB+FGL2, or RCAS-FGL2 groups. B and C) CD44 and Olig2 expression in RCAS-PDGFB and RCAS-PDGFB+FGL2 LGGs and HGGs. Immunohistochemical staining of representative tumor sections (magnification, 400×; scale bar = 50 μm). Left) Scatter plot demonstrating differences in CD44 and Olig2 expression between the two groups (t test, two-sided). FGL2 = fibrinogen-like protein 2; HGG = high-grade glioma; LGG = low-grade glioma; PDGF = platelet-derived growth factor; PDGFB = platelet-derived growth factor subunit B.