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EC arginase 1 deletion or arginase inhibition prevents HFHS-induced aortic stiffening and fibrosis. Effects of arginase 1 deletion or ABH on pulse wave velocity (A) and collagen deposition (B, C). Representative sections stained with Picrosirius Red (C). Values are mean ± SEM, n = 5–6. *P < 0.05 vs. ND.
