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EC arginase 1 deletion or arginase inhibition prevents HFHS or PA/HG -induced decreases in vascular nitric oxide. Effects of EC arginase 1 deletion or ABH on fluorescence for the NO indicator DAF2-DA (A). Representative images of DAF2-DA fluorescence (B). Values are mean ± SEM, n = 5–6. *P < 0.05 vs. ND. Effects of EC arginase 1 deletion on NO production in aorta exposed to PA/HG ex vivo (C). Values are mean ± SEM, n = 5. *P < 0.05 vs. control media (NG).
