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. 2017 Sep 7;113(13):1664–1676. doi: 10.1093/cvr/cvx164

Figure 7.

Figure 7

EC arginase 1 deletion or arginase inhibition prevents HFHS-induced increases in ROS levels. (A) Effects of arginase 1 deletion or ABH on plasma malonaldehyde (MDA) and (B) aortic fluorescence for the ROS indicator dihydroethidium (DHE). (C) Representative images of DHE fluorescence. Values are mean ± SEM, n = 5–6. *P< 0.05 vs. ND. (D) Levels of the peroxynitrite marker—3-nitrotyrosine in aorta from A1con and ECA1−/− mice exposed to normal glucose control media (CM) or palmitic acid and high glucose (PA/HG) for 24 h. Values are mean ± SEM, n = 5. *P< 0.05 vs. NG.