. 2017 Sep 7;113(13):1664–1676. doi: 10.1093/cvr/cvx164

Table 1.

Body weight, blood glucose, glycated hemoglobin (HbA1C), blood pressure, serum insulin, and plasma cholesterol

		Body weight (g)	Blood glucose (mg/dL)	HbA1C (%) (mmol/mol)	Systolic blood pressure (mmHg)	Insulin after feeding (ng/mL)	Cholesterol (mg/dL)
WT	ND	37.7 ± 1.4	110.8 ± 3.4	4.4 ± 0.2	94.3 ± 2.5	0.4 ± 0.02	115.5 ± 3.9
	ND	37.7 ± 1.4	110.8 ± 3.4	24.3 ± 0.9	94.3 ± 2.5	0.4 ± 0.02	115.5 ± 3.9
	HFHS	51.9 ± 1.9*	201.4 ± 16.9*	5.3 ± 0.2*	120.2 ± 5.7*	1.6 ± 0.3*	217.2 ± 23.4*
	HFHS	51.9 ± 1.9*	201.4 ± 16.9*	34.0 ± 1.0*	120.2 ± 5.7*	1.6 ± 0.3*	217.2 ± 23.4*
	ND +	37.3 ± 1.6	107.5 ± 3.1	4.4 ± 0.2	92.3 ± 1.6	0.3 ± 0.05	98.2 ± 4.5
	ABH	37.3 ± 1.6	107.5 ± 3.1	24.4 ± 1.2	92.3 ± 1.6	0.3 ± 0.05	98.2 ± 4.5
	HFHS+	49.3 ± 1.8*	195.7 ± 18.4*	5.1 ± 0.13*	99.4 ± 1.5	1.0 ± 0.2 #	182.1 ± 18.5*
	ABH	49.3 ± 1.8*	195.7 ± 18.4*	32.2 ± 0.8*	99.4 ± 1.5	1.0 ± 0.2 #	182.1 ± 18.5*
EC-KO	ND A1^con	36.8 ± 1.4	106.8 ± 3.9	4.5 ± 0.1	96.3 ± 2.3	0.7 ± 0.2	120.1 ± 9.3
	ND A1^con	36.8 ± 1.4	106.8 ± 3.9	26.0 ± 0.8	96.3 ± 2.3	0.7 ± 0.2	120.1 ± 9.3
	HFHS A1con	50.7 ± 1.3*	197.8 ± 10.5*	5.2 ± 0.1*	115.9 ± 4.2*	2.3 ± 0.2*	190.7 ± 4.6*
	HFHS A1con	50.7 ± 1.3*	197.8 ± 10.5*	33.6 ± 0.5*	115.9 ± 4.2*	2.3 ± 0.2*	190.7 ± 4.6*
	ND	38.7 ± 1.3	102.7 ± 2.4	4.5 ± 0.2	92.7 ± 1.4	0.8 ± 0.4	104.7 ± 10.5
	EC-A1^−/−	38.7 ± 1.3	102.7 ± 2.4	25.5 ± 1.0	92.7 ± 1.4	0.8 ± 0.4	104.7 ± 10.5
	HFHS	49.5 ± 1.4*	199.6 ± 11.3*	5.2 ± 0.2*	98.9 ± 3.1	1.7 ± 0.3*	219.5 ± 6.0*
	EC-A1^−/−	49.5 ± 1.4*	199.6 ± 11.3*	32.9 ± 1.0*	98.9 ± 3.1	1.7 ± 0.3*	219.5 ± 6.0*

Values are means ± S.E.M. *P < 0.05 vs. WT or A1^con mice on normal diet (ND), # P < 0.05 vs. WT mice on HFHS diet, n = 4–6. Abbreviations: endothelial cell specific knockout of A1 (EC-A1^−/−), high fat high sucrose diet (HFHS), and arginase inhibitor, 2-(S)-amino-6-boronohexanoic acid (ABH).