Fig. 6.

Model of how OGT regulates Oct4 transcriptional activation of two different promoters. OGT regulates transcriptional activity of Oct4 by two different mechanisms. OGT transfers O-GlcNAc to Oct4 C-terminal domain to activate the monomer promoter. Modification of Oct4 at S236 represses activation of the heterodimer (Oct/Sox) promoter. OGT is hypothesized to participate in activation of heterodimer promoter independently of modification by directly interacting with the Oct/Sox complex (dotted line). This figure is available in black and white in print and in color at Glycobiology online.