Table III.
Comparison of clinical and biochemical characteristics between different genotypes of FTO gene polymorphism rs8050136: A>C in healthy subjects.
| FTO rs8050136 A>C | ||||||
|---|---|---|---|---|---|---|
| AA (n=79) | AC (n=140) | CC (n=87) | p-value AA/AC | p-value AA/CC | p-value AC/CC | |
| Fasting glucose (mmol/L) | 5.02 ± 0.138 | 5.18 ± 0.055 | 5.15 ± 0.117 | 0.996 | 0.561 | 0.502 |
| HbA1c (%) | 9.37 ± 3.811 | 5.47 ± 0.048 | 5.39 ± 0.062 | 0.119 | 0.016 | 0.246 |
| Fasting insulin (mU/L) | 11.27 ± 2.227 | 11.17 ± 1.105 | 10.443 ± 0.801 | 0.674 | 0.486 | 0.751 |
| + HOMA-IR | 2.212 ± 0.206 | 2.629 ± 0.282 | 2.49 ± 0.217 | 0.744 | 0.618 | 0.842 |
| BMI (kg/m2) | 29.41 ± 2.661 | 26.91 ± 0.589 | 27.02 ± 0.805 | 0.133 | 0.221 | 0.880 |
| Waist circumference (cm) | 98.55 ± 1.638 | 94.07 ± 1.012 | 92.78 ± 2.008 | 0.163 | 0.076 | 0.630 |
| Hip circumference (cm) | 109.25 ± 1.498 | 106.27 ± 0.884 | 106.55 ± 2.574 | 0.414 | 0.635 | 0.194 |
| Systolic BP (mm Hg) | 123.05 ± 2.181 | 120.43 ± 1.803 | 126.75 ± 2.107 | 0.375 | 0.175 | 0.108 |
| Diastolic BP (mm Hg) | 82.65 ± 1.128 | 79.13 ± 0.665 | 80.43 ± 1.112 | 0.020 | 0.362 | 0.179 |
| Triglycerides (mmol/L) | 1.75 ± 0.137 | 1.66 ± 0.082 | 1.64 ± 0.112 | 0.781 | 0.835 | 0.600 |
| Total cholesterol (mmol/L) | 5.37 ± 0.167 | 5.44 ± 0.106 | 5.36 ± 0.157 | 0.521 | 0.679 | 0.850 |
| HDL cholesterol (mmol/L) | 1.21 ± 0.054 | 1.34 ± 0.040 | 1.27 ± 0.051 | 0.040 | 0.169 | 0.585 |
| LDL-cholesterol (mmol/L) | 3.51 ± 0.119 | 3.45 ± 0.088 | 3.48 ± 0.115 | 0.426 | 0.414 | 0.914 |
| VLDL-cholesterol (mmol/L) | 0.735 ± 0.118 | 0.822 ± 0.089 | 0.687 ± 0.066 | 0.152 | 0.576 | 0.365 |
| hsCRP (mg/L) | 3.72 ± 0.433 | 3.39 ± 0.228 | 3.66 ± 0.428 | 0.896 | 0.964 | 0.933 |
| Fibrinogen (g/L) | 5.30 ± 1.584 | 3.81 ± 0.601 | 3.11 ± 0.083 | 0.035 | 0.013 | 0.439 |
| Leukocytes (109/L) | 6.77 ± 0.192 | 6.19 ± 0.170 | 6.44 ± 0.235 | 0.006 | 0.133 | 0.330 |
| Sedimentation (mm/h) | 12.65 ± 2.893 | 11.13 ± 1.320 | 10.06 ± 2.518 | 0.820 | 0.801 | 0.937 |
Values represent mean ± standard error mean (SEM), p-values show the significance of the differences of clinical and biochemical characteristics between the stated genotypes of FTO gene polymorphism rs8050136: A>C. All differences were tested using ANCOVA test (adjusted for age, sex and BMI).