Table IV.

Comparison of clinical and biochemical characteristics between different genotypes of FTO gene polymorphism rs8050136: A>C in T2D patients treated with hypoglycemics.

	FTO rs8050136 A>C
	AA (n = 104)	AC (n = 203)	CC (n=107)	p-value AA/AC	p-value AA/CC	p-value AC/CC
Fasting glucose (mmol/L)	8.86 ± 0.361	9.50 ± 0.280	9.16 ± 0.392	0.124	0.830	0.185
HbA1c (%)	7.57 ± 0.172	7.74 ± 0.124	7.53 ± 0.154	0.639	0.794	0.435
Fasting insulin (mU/L)	16.95 ± 2.283	15.29 ± 0.990	15.65 ± 1.449	0.856	0.480	0.291
+ HOMA-IR	6.96 ± 1.238	6.30 ± 0.434	6.65 ± 0.716	0.532	0.603	0.186
BMI (kg/m2)	30.76 ± 0.727	30.98 ± 0.411	30.98 ± 0.805	0.377	0.980	0.381
Waist circumference (cm)	101.09 ± 2.021	103.32 ± 0.859	101.77 ± 1.814	0.346	0.268	0.731
Hip circumference (cm)	107.83 ± 2.821	110.92 ± 0.945	107.23 ± 2.060	0.139	0.067	0.503
Systolic BP (mm Hg)	134.48 ± 2.878	138.50 ± 2.275	136.87 ± 1.973	0.154	0.654	0.049
Diastolic BP (mm Hg)	88.37 ± 1.088	88.09 ± 0.763	87.16 ± 1.054	0.516	0.322	0.621
Triglycerides (mmol/L)	2.38 ± 0.259	2.31 ± 0.100	2.78 ± 0.428	0.390	0.209	0.557
Total cholesterol (mmol/L)	5.21 ± 0.130	5.17 ± 0.118	5.29 ± 0,167	0.484	0.616	0.899
HDL-cholesterol (mmol/L)	1.11 ± 0.036	1.03 ± 0.022	1.03 ± 0.031	0.295	0.083	0.341
LDL-cholesterol (mmol/L)	3.29 ± 0.118	3.33 ± 0.089	3.36 ± 0.155	0.841	0.740	0.855
VLDL-cholesterol (mmol/L)	0.80 ± 0.064	1.51 ± 0.211	1.71 ± 0.438	0.011	0.021	0.988
hsCRP (mg/L)	6.31 ± 1.292	4.69 ± 0.557	5.64 ± 1.091	0.182	0.172	0.821
Fibrinogen (g/L)	3.60 ± 0.149	3.60 ± 0.114	3.76 ± 0.137	0.761	0.666	0.393
Leukocytes (109/L)	7.12 ± 0.225	7.57 ± 0.169	7.50 ± 0.311	0.132	0.407	0.609
Sedimentation (mm/h)	13.38 ± 2.941	18.58 ± 4.092	16.19 ± 2.940	0.543	0.178	0.356

Values represent mean ± standard error mean (SEM), p-values show the significance of the differences of clinical and biochemical characteristics between the stated genotypes of FTO gene polymorphism rs8050136: A>C. All differences were tested using ANCOVA test (adjusted for age, sex and BMI).