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. Author manuscript; available in PMC: 2019 Mar 11.
Published in final edited form as: Cell Rep. 2018 Jun 26;23(13):3787–3797. doi: 10.1016/j.celrep.2018.04.099

Figure 1. Somatic Cell Gene Transfer of C11orf95-RELA into Nestin-Expressing Cells Drives Brain Tumorigenesis.

Figure 1.

(A) Schematic of various RCAS vectors. Blue and red boxes represent components of C11orf95 and RELA coding sequences, respectively. Z, zinc finger (C2H2-like); RHD, Rel homology domain; AD, activation domain; orange box, 9aaTAD; H, HA tag. The phosphorylation and acetylation sites of the RELAFUS1 gene product corresponding to those of RELA are also described.

(B) Kaplan-Meier survival curves showing symptom-free survival of RCAS-RELAFUS1 (black line) and RELAFUS1-HA(red line), RELA-HA (blue line), or C11orf95-HA (green line) injection in Nestin (N)/tv-a (regular line) or N/tv-a;Ink4a-Arf−/− (dotted line) mice. Tumor formation was observed by injection of these RCAS viruses into neonatal pups brains. n.s., not significant.

(C) Summary of the RCAS vector injections in N/tv-a or N/tv-a;Ink4a-Arf−/−.