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. Author manuscript; available in PMC: 2019 Mar 11.
Published in final edited form as: Cell Rep. 2018 Jun 26;23(13):3787–3797. doi: 10.1016/j.celrep.2018.04.099

Figure 2. RELAFUS1-induced Mouse Tumors Recapitulate Human ST-EPN Histology.

Figure 2.

(A) Representative H&E and immunohistochemistry (IHC) images of RCAS-RELAFUS1-HA-, PDGFA-, and GPT53N-induced brain tumors in the indicated tv-a mice. HA, PDGFA, and GFP antibody immunoexpression represents essentially the vector expression. Dashed boxes at the top denote the enlarged regions as shown at the bottom. Scale bars, 100 μm.

(B) Representative H&E stainings of RELAFUS1-induced brain tumors in N/tv-a;Ink4a-Arf−/− mice, human RELAFUS1-positive ST-ependymoma, and human GBM. Scale bars, 100 μm.

(C) Representative H&E and IHC analysis with the indicated antibodies of RCAS-RELAFUS1-induced brain tumors in N/tv-a mice. All enlarged images represent the areas of dashed boxes in H&E staining. Scale bars, 100 μm.

(D) Representative ultra-structure of a RELAFUS1-induced brain tumor. Black arrowheads show interdigitating tumor cell processes.