Table 1. Pearson’s correlation coefficients between expression of genes in TGF-β signalling with other genes in TGF-β signalling, stromal matrix and marker and thecal cells and gestational age.
TGF-β Signalling | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
TGFB1 | TGFB2 | TGFB3 | TGFBR1 | TGFBR2 | TGFBR3 | LTBP1 | LTBP2 | LTBP3 | LTBP4 | TGFB1I1 | ||
Gestational age | -0.330 | 0.818d | 0.758c | 0.121 | 0.838d | 0.930d | 0.454 | 0.957d | 0.857d | 0.855d | 0.895d | |
TGF-β Signalling | TGFB1 | -0.441 | -0.282 | -0.033 | -0.298 | -0.499a | -0.418 | -0.395 | -0.228 | -0.334 | -0.452 | |
TGFB2 | -0.441 | 0.720b | 0.092 | 0.861c | 0.945c | 0.575a | 0.863c | 0.796c | 0.796c | 0.954c | ||
TGFB3 | -0.282 | 0.720b | 0.418 | 0.832c | 0.764c | 0.665b | 0.630b | 0.850c | 0.920c | 0.776c | ||
TGFBR1 | -0.033 | 0.092 | 0.418 | 0.110 | 0.076 | 0.604a | 0.107 | 0.34 | 0.279 | 0.082 | ||
TGFBR2 | -0.298 | 0.861c | 0.832c | 0.110 | 0.900c | 0.457 | 0.857c | 0.902c | 0.943c | 0.928c | ||
TGFBR3 | -0.499a | 0.945c | 0.764c | 0.076 | 0.900c | 0.617b | 0.849c | 0.801c | 0.883c | 0.968c | ||
LTBP1 | -0.418 | 0.575a | 0.665b | 0.604a | 0.457 | 0.617b | 0.469 | 0.497a | 0.617b | 0.554a | ||
LTBP2 | -0.395 | 0.863c | 0.630b | 0.107 | 0.857c | 0.849c | 0.469 | 0.784c | 0.758c | 0.893c | ||
LTBP3 | -0.228 | 0.796c | 0.850c | 0.340 | 0.902c | 0.801c | 0.497a | 0.784c | 0.916c | 0.864c | ||
LTBP4 | -0.334 | 0.796c | 0.920c | 0.279 | 0.943c | 0.883c | 0.617b | 0.758c | 0.916c | 0.891c | ||
TGFB1I1 | -0.452 | 0.954c | 0.776c | 0.082 | 0.928c | 0.968c | 0.554a | 0.893c | 0.864c | 0.891c | ||
Stromal Matrix and Marker | NR2F2 | -0.049 | 0.652b | 0.740c | 0.443 | 0.786c | 0.590a | 0.352 | 0.691b | 0.855c | 0.752c | 0.695b |
COL1A1 | -0.436 | 0.944c | 0.661b | -0.077 | 0.822c | 0.936c | 0.479 | 0.859c | 0.718b | 0.745c | 0.926c | |
COL3A1 | -0.398 | 0.959c | 0.676b | -0.017 | 0.863c | 0.946c | 0.488a | 0.884c | 0.737c | 0.761c | 0.930c | |
FBN1 | -0.503a | 0.945c | 0.572a | 0.044 | 0.735c | 0.870c | 0.533a | 0.799c | 0.712b | 0.655b | 0.887c | |
FBN2 | -0.039 | 0.057 | 0.249 | 0.815c | -0.147 | -0.043 | 0.632b | -0.071 | 0.113 | 0.038 | -0.036 | |
FBN3 | 0.251 | -0.837c | -0.726c | -0.034 | -0.856c | -0.844c | -0.485a | -0.868c | -0.842c | -0.821c | -0.866c | |
Steroidogenesis and growth factor signalling | INSL3 | -0.319 | 0.462 | 0.041 | -0.413 | 0.489a | 0.459 | 0.063 | 0.624b | 0.250 | 0.294 | 0.498a |
CYP17A1 | -0.357 | 0.323 | -0.063 | -0.411 | 0.338 | 0.390 | 0.034 | 0.407 | 0.069 | 0.187 | 0.365 | |
CYP11A1 | -0.338 | 0.333 | 0.026 | -0.356 | 0.428 | 0.379 | 0.047 | 0.508a | 0.160 | 0.257 | 0.395 | |
HSD3B1 | -0.269 | 0.210 | -0.006 | -0.321 | 0.375 | 0.284 | 0.018 | 0.433 | 0.102 | 0.223 | 0.293 | |
LHCGR | 0.060 | -0.570a | -0.717b | -0.159 | -0.607b | -0.579a | -0.425 | -0.459 | -0.769c | -0.719b | -0.597a | |
AR | -0.455 | 0.898c | 0.868c | 0.298 | 0.866c | 0.942c | 0.720b | 0.762c | 0.874c | 0.930c | 0.929c | |
RARRES1 | -0.094 | 0.579a | 0.336 | -0.108 | 0.489a | 0.490a | 0.082 | 0.680b | 0.480 | 0.348 | 0.537a | |
IGFBP3 | -0.224 | 0.541a | 0.646b | 0.156 | 0.567a | 0.646b | 0.646b | 0.416 | 0.441 | 0.648b | 0.568a |