. 2019 Mar 11;14(3):e0213575. doi: 10.1371/journal.pone.0213575

Table 1. Pearson’s correlation coefficients between expression of genes in TGF-β signalling with other genes in TGF-β signalling, stromal matrix and marker and thecal cells and gestational age.

The darker the background colour the more significant the correlation is. Blue indicates a negative correlation and red indicates a positive correlation. (P-values: a < 0.05, b < 0.01, c < 0.001, d < 0.0001).

		TGF-β Signalling
		TGFB1	TGFB2	TGFB3	TGFBR1	TGFBR2	TGFBR3	LTBP1	LTBP2	LTBP3	LTBP4	TGFB1I1
Gestational age		-0.330	0.818^d	0.758^c	0.121	0.838^d	0.930^d	0.454	0.957^d	0.857^d	0.855^d	0.895^d
TGF-β Signalling	*TGFB1*		-0.441	-0.282	-0.033	-0.298	-0.499^a	-0.418	-0.395	-0.228	-0.334	-0.452
	*TGFB2*	-0.441		0.720^b	0.092	0.861^c	0.945^c	0.575^a	0.863^c	0.796^c	0.796^c	0.954^c
	*TGFB3*	-0.282	0.720^b		0.418	0.832^c	0.764^c	0.665^b	0.630^b	0.850^c	0.920^c	0.776^c
	*TGFBR1*	-0.033	0.092	0.418		0.110	0.076	0.604^a	0.107	0.34	0.279	0.082
	*TGFBR2*	-0.298	0.861^c	0.832^c	0.110		0.900^c	0.457	0.857^c	0.902^c	0.943^c	0.928^c
	*TGFBR3*	-0.499^a	0.945^c	0.764^c	0.076	0.900^c		0.617^b	0.849^c	0.801^c	0.883^c	0.968^c
	*LTBP1*	-0.418	0.575^a	0.665^b	0.604^a	0.457	0.617^b		0.469	0.497^a	0.617^b	0.554^a
	*LTBP2*	-0.395	0.863^c	0.630^b	0.107	0.857^c	0.849^c	0.469		0.784^c	0.758^c	0.893^c
	*LTBP3*	-0.228	0.796^c	0.850^c	0.340	0.902^c	0.801^c	0.497^a	0.784^c		0.916^c	0.864^c
	*LTBP4*	-0.334	0.796^c	0.920^c	0.279	0.943^c	0.883^c	0.617^b	0.758^c	0.916^c		0.891^c
	*TGFB1I1*	-0.452	0.954^c	0.776^c	0.082	0.928^c	0.968^c	0.554^a	0.893^c	0.864^c	0.891^c
Stromal Matrix and Marker	*NR2F2*	-0.049	0.652^b	0.740^c	0.443	0.786^c	0.590^a	0.352	0.691^b	0.855^c	0.752^c	0.695^b
	*COL1A1*	-0.436	0.944^c	0.661^b	-0.077	0.822^c	0.936^c	0.479	0.859^c	0.718^b	0.745^c	0.926^c
	*COL3A1*	-0.398	0.959^c	0.676^b	-0.017	0.863^c	0.946^c	0.488^a	0.884^c	0.737^c	0.761^c	0.930^c
	*FBN1*	-0.503^a	0.945^c	0.572^a	0.044	0.735^c	0.870^c	0.533^a	0.799^c	0.712^b	0.655^b	0.887^c
	*FBN2*	-0.039	0.057	0.249	0.815^c	-0.147	-0.043	0.632^b	-0.071	0.113	0.038	-0.036
	*FBN3*	0.251	-0.837^c	-0.726^c	-0.034	-0.856^c	-0.844^c	-0.485^a	-0.868^c	-0.842^c	-0.821^c	-0.866^c
Steroidogenesis and growth factor signalling	*INSL3*	-0.319	0.462	0.041	-0.413	0.489^a	0.459	0.063	0.624^b	0.250	0.294	0.498^a
	*CYP17A1*	-0.357	0.323	-0.063	-0.411	0.338	0.390	0.034	0.407	0.069	0.187	0.365
	*CYP11A1*	-0.338	0.333	0.026	-0.356	0.428	0.379	0.047	0.508^a	0.160	0.257	0.395
	*HSD3B1*	-0.269	0.210	-0.006	-0.321	0.375	0.284	0.018	0.433	0.102	0.223	0.293
	*LHCGR*	0.060	-0.570^a	-0.717^b	-0.159	-0.607^b	-0.579^a	-0.425	-0.459	-0.769^c	-0.719^b	-0.597^a
	AR	-0.455	0.898^c	0.868^c	0.298	0.866^c	0.942^c	0.720^b	0.762^c	0.874^c	0.930^c	0.929^c
	*RARRES1*	-0.094	0.579^a	0.336	-0.108	0.489^a	0.490^a	0.082	0.680^b	0.480	0.348	0.537^a
	*IGFBP3*	-0.224	0.541^a	0.646^b	0.156	0.567^a	0.646^b	0.646^b	0.416	0.441	0.648^b	0.568^a