Table 4. Path analysis aimed at estimating the treatment effect on lrna6 by INSTI in analysis with FPR < 10%.
The 4 regression steps defining the path to the final outcome (lrna6) are reported in the first 4 sections of the table. Female, age, and x4_10 were exogenous variables, whereas lrna6, lrna0, lcd4_0, and therapy with INSTI were endogenous variables. The selection bias due to the choice of treatment was adjusted using INSTI as mediator variable, and all baseline information as explanatory set.
| Standardized | Coef. | Std. Err. | z | p | 95% Conf. Interval | |
|---|---|---|---|---|---|---|
| lrna6 | ||||||
| lrna0 | 0.3475996 | 0.0460461 | 7.55 | 0 | 0.2573509 | 0.4378483 |
| INSTI | -0.3070178 | 0.118647 | -2.59 | 0.01 | -0.5395616 | -0.074474 |
| Female | 0.0649282 | 0.0578053 | 1.12 | 0.261 | -0.0483681 | 0.1782244 |
| Age (years) | 0.0293828 | 0.0450441 | 0.65 | 0.514 | -0.058902 | 0.1176675 |
| Intercept | 0.4924667 | 0.3763257 | 1.31 | 0.191 | -0.2451182 | 1.230052 |
| lrna0 | ||||||
| lcd4_0 | -0.3523528 | 0.0327359 | -10.76 | 0 | -0.416514 | -0.2881916 |
| Female | -0.1355738 | 0.0436358 | -3.11 | 0.002 | -0.2210984 | -0.0500492 |
| Age (years) | 0.0090896 | 0.0419573 | 0.22 | 0.828 | -0.0731452 | 0.0913244 |
| Intercept | 7.804966 | 0.3040944 | 25.67 | 0 | 7.208952 | 8.40098 |
| INSTI | ||||||
| lrna0 | 0.1029556 | 0.1038976 | 0.99 | 0.322 | -0.10068 | 0.3065911 |
| lcd4_0 | 0.1607515 | 0.0822961 | 1.95 | 0.051 | -0.000546 | 0.3220489 |
| Female | -0.0989271 | 0.0935878 | -1.06 | 0.29 | -0.2823558 | 0.0845015 |
| Age (years) | 0.0131043 | 0.0987351 | 0.13 | 0.894 | -0.180413 | 0.2066216 |
| x4_10 | -0.113774 | 0.0795612 | -1.43 | 0.153 | -0.2697111 | 0.0421631 |
| Intercept | -0.4668823 | 0.9372217 | -0.5 | 0.618 | -2.303803 | 1.370038 |
| lcd4_0 | ||||||
| Female | -0.0794107 | 0.0414308 | -1.92 | 0.055 | -0.1606136 | 0.0017921 |
| Age (years) | -0.1509164 | 0.0384372 | -3.93 | 0 | -0.2262518 | -0.0755809 |
| x4_10 | -0.1323374 | 0.0444933 | -2.97 | 0.003 | -0.2195426 | -0.0451322 |
| Intercept | 5.028884 | 0.2386328 | 21.07 | 0 | 4.561173 | 5.496596 |
| var (e.lrna6) | 0.7907716 | 0.0705402 | 0.6639269 | 0.9418502 | ||
| var (e.lrna0) | 0.8616431 | 0.0249203 | 0.8141589 | 0.9118968 | ||
| var (e.ii) | 0.9460575 | 0.0448505 | 0.8621125 | 1.038176 | ||
| var (e.lcd4_0) | 0.9550003 | 0.0168778 | 0.9224868 | 0.9886598 | ||
Discr. test of model vs. saturated: chi2(3) = 0.56, Prob > chi2 = 0.9052
x4_10: co-receptor HIV tropism as X4 with FPR ≤ 10%; lcd4_0: log10-transformed CD4+ cell count at T0; lcd4_6: log10-transformed CD4+ cell count after 6 months of cART; lrna0: log10-transformed plasma HIV RNA at T0; lrna6: log10-transformed plasma HIV RNA after 6 months of cART; INSTI: integrase inhibitors