Table 3. Changes of hemodynamic and laboratory parameters at 15 and 60 min following start of transfusion.
Data are depicted as mean±standard deviation. P-values (Welch’s t-Test) indicate differences among patients receiving fresh and standard-issue PRBCs. Statistically significant data are printed bold. Abbreviations: Δ15, change in parameter during transfusion; Δ60, change in parameter within the first 60 minutes after starting transfusion; CI, cardiac index; Hb, hemoglobin; MIF, macrophage migration inhibitory factor; PAP, pulmonary arterial pressure; PRBCs, packed red blood cells; PVRI, pulmonary vascular resistance index; SDC, syndecan-1; SVRI, systemic vascular resistance index; MAP, mean arterial pressure; CI, cardiac index.
| Δ 15 | Δ 60 | |||||
|---|---|---|---|---|---|---|
| Parameter | Fresh PRBCs |
Standard-issue PRBCs |
P-value | Fresh PRBCs | Standard-issue PRBCs |
P-value |
| PAP (mmHg) | 2±2 | 7±3 | 0.012 | 1±2 | 3±1 | 0.079 |
| PVRI (dyn·s·cm-5·m2) | -4±79 | 150±89 | 0.016 | 35±90 | 47±22 | 0.761 |
| MAP (mmHg) | 4±3 | 8±5 | 0.116 | 0±5 | 7±6 | 0.076 |
| SVRI (dyn·s·cm-5·m2) | 25±140 | 303±106 | 0.005 | 154±624 | 121±192 | 0.907 |
| CI (L·min-1·m2) | 0.1±0.2 | -0.2±0.4 | 0.183 | -0.1±0.3 | 0±0.3 | 0.540 |
| SDC (ng/ml) | 1±2 | 3±3 | 0.497 | 0±1 | 4±8 | 0.348 |
| MIF (ng/ml) | -1±10 | 13±22 | 0.233 | 4±21 | 14±12 | 0.333 |
| Free Hb (mg/dl) | 1±1 | 8±8 | 0.141 | 1±1 | 4±5 | 0.185 |