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A schematic hypothetical model shows how DDX5 regulates autophagy to affect cell proliferation and tumorigenesis in HCC. DDX5 binds p62 and interferes with p62/TRAF6 interaction, suppressing mTOR signaling. MiR-17–5p inhibition upregulates DDX5 expression and promotes autophagy activity and p62 elimination, thereby suppressing cell proliferation and tumor formation.
