A and B Unadjusted hormonal (ACTH - upper panel, 3A; cortisol = lower panel, 3B) concentrations on the placebo test day. After adjusting for baseline effects, corticotropin levels in women increased over time compared with men (Sex x Time interaction, p < 0.006). Morning cortisol concentrations were significantly lower in women than men (main Sex effect, p < 0.04), but gradually increased over time (Sex x Time interaction, p < 0.03). Mean ± SEM shown.