Table 2.
Multivariate relative risks (RR) and 95% confidence intervals (CI) of prostate cancer in relation to history of diabetes, PLCO study
Prostate cancer | History of diabetes |
|
---|---|---|
No | Yes | |
Total cases | 1,905 | 153 |
RR (95% CI)a | 1.00 (ref) | 0.80 (0.68–0.95) |
Low grade (Gleason sum <8) cases | 1,700 | 135 |
RR (95% CI)a | 1.00 (ref) | 0.81 (0.68–0.96) |
High grade (Gleason sum ≥8) cases | 173 | 16 |
RR (95% CI)a | 1.00 (ref) | 0.84 (0.50–1.41) |
Low stage (stages I–II) cases | 1,624 | 125 |
RR (95% CI)a | 1.00 (ref) | 0.76 (0.63–0.91) |
High stage (stages III–IV) cases | 279 | 28 |
RR (95% CI)a | 1.00 (ref) | 1.09 (0.73–1.62) |
Non-aggressive (low grade and low stage) cases | 1,494 | 112 |
RR (95% CI)a | 1.00 (ref) | 0.75 (0.62–0.91) |
Aggressive (high grade or high stage) cases | 383 | 39 |
RR (95% CI)a | 1.00 (ref) | 1.04 (0.74–1.45) |
Relative risk adjusted for age, race, family history of prostate cancer, study center, aspirin use, education, smoking, body mass index, physical activity, and height. Number of cases by grade or stage may not sum to total cases due to missing information on grade or stage