Table II.

Distribution of primary tumor sites in patients with somatic TP53 mutations.

p53 mutation	Colon, n	Lung, n	Breast, n	Ovary, n	Brain, n	Esophagus, n	Bladder, n	Other, n	P-valuea	Q
NULL	548	686	749	596	221	464	242	2333	-	-
MIS	2326	2307	2304	1632	1542	1423	1159	9114	< 0.0001	0.0001
R248Q	159	37	113	54	75	49	53	415	< 0.0001	0.0001
R248W	147	47	84	58	57	60	25	292	< 0.0001	0.0001
R175H	290	37	131	107	107	99	38	412	< 0.0001	0.0001
R273H	165	54	98	94	80	47	21	304	< 0.0001	0.0001

^aVersus NULL group. p53, tumor suppressor p53; MIS, any missense mutation.