Table V.
Frequency of metastasis in patients with somatic TP53 mutations.
| p53 mutation | M1 | M0 | P-value | Q | OR (95% CI) | % M1 |
|---|---|---|---|---|---|---|
| NULL | 200 | 3649 | - | - | - | 5.2 |
| MISa | 499 | 13242 | <0.0001 | 0.0005 | 0.6875 (0.5811-0.8134) | 3.6 |
| R248Qa | 18 | 561 | 0.0393 | 0.0983 | 0.5854 (0.3584-0.9561) | 3.1 |
| R248W | 23 | 484 | 0.5987 | 0.9267 | - | 4.5 |
| R175H | 41 | 772 | 0.9267 | 0.9267 | - | 5.0 |
| R273H | 29 | 487 | 0.7638 | 0.9267 | - | 5.6 |
a
P<0.05 and Q<0.1 vs. NULL group. M1/M0, number of patients with/without metastasis; % M1, percentage of patients with metastasis; MIS, any missense mutation; OR, odds ratio; CI, confidence interval.