Table VI.

Distribution of metastasis location sites in patients with somatic TP53 mutations from the International Agency for Research on Cancer database.

p53 mutation	Liver, n	Lymph node, n	Other, n	P-value	Q
NULL	82	36	82	-	-
MISa	226	114	159	0.0603	0.0905
R248Q	9	3	6	0.7493	0.7493
R248W	11	6	6	0.3483	0.4180
R175Ha	27	3	11	0.0122	0.0244
R273Ha	22	2	5	0.002	0.0060
3-GENEa	69	14	28	0.0016	0.0060

^aP<0.05 and Q<0.1 vs. NULL group. p53, tumor suppressor p53; MIS, any missense mutation; 3-GENE, any one of R175H, R248Q, R248W or R273H mutations.