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. 2019 Feb 22;54(4):1168–1182. doi: 10.3892/ijo.2019.4723

Table VII.

Distribution of metastasis location sites in patients with somatic TP53 mutations from the Memorial Sloan Kettering Cancer Center database.

p53 mutation Liver, n Lymph node, n Lung, n Bone, n Brain, n Other, n Versus NULL group
Versus WT group
P-value Q P-value Q
WTa 482 506 350 213 76 975 <0.0001 0.0007 - -
MISSb 389 264 141 75 57 465 0.7006 0.7006 <0.0001 0.0001
NULLb 231 158 97 41 43 266 - - <0.0001 0.0001
R248Qb 18 11 2 4 3 31 0.1411 0.1768 0.0728 0.0849
R248Wb 22 5 3 1 3 13 0.0899 0.1573 <0.0001 0.0001
R175Hb 36 10 5 3 4 28 0.0633 0.1477 <0.0001 0.0001
R273H 13 11 5 0 1 26 0.1515 0.1768 0.1871 0.1871
3-GENEa,b 89 37 15 8 11 98 0.0071 0.0249 <0.0001 0.0001
a

P<0.05 and Q<0.1 vs. NULL group;

b

P<0.05 and Q<0.1 vs. WT group. p53, tumor suppressor p53; WT, wild-type; MIS, any missense mutation; 3-GENE, R175H, R248Q, R248W and R273H mutations.