Figure 7.

CGK062 treatment inhibits CUG2-induced tumor development in vivo. (A and B) Balb/C nude mice were subcutaneously transplanted with A549-CUG2 cells (1×10⁶ cells/mouse) for 2 weeks and were intraperitoneally injected with CGK062 (100 mg/kg body weight) for 4 weeks. Tumor sizes and body weights were measured for 4 weeks [^**P<0.01, mock (n=6) vs. CGK062 (n=6); ns; not significant]. (C) At 4 weeks after the treatment, tumor tissues harvested from the mice were embedded in paraffin and were sectioned for performing the TUNEL assay. Green fluorescence indicates apoptotic cells.