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. 2019 Feb 1;54(4):1183–1194. doi: 10.3892/ijo.2019.4707

Figure 6.

Figure 6

High PLAC2 is associated with poor survival of patients with OSCC. (A) The correlations of the RNA expression between PLAC2 and CBP, and PLAC2 and β-catenin in OSCC tissues were analyzed by Spearman's correlation test. (B) A receiver operating curves was used to determine the diagnostic value of PLAC2 in distinguishing patients with OSCC from healthy population. (C) Overall survival and (D) progressive-free survival of the 48 patients as represented by Kaplan-Meier curves. Expression level of PLAC2 was categorized into high and low using the median value. (E) A scheme of the proposed mechanisms, the histone H3 on lysine 27 acetylation-induced PLAC2 expression promotes tumor growth and metastasis by the activation of Wnt/β-catenin pathway. PLAC2, placenta-specific protein 2; CBP, cAMP-response element binding protein-binding protein; AUC, area under the curve; OSCC, oral squamous cell carcinoma; lnc, long non-coding.