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Zoledronic Acid Dosing
| Variables | Interval | |
|---|---|---|
|
| ||
| Standard (n = 121) | Extended (n = 35) | |
| No. doses, mean (SD) | 11.4 (13.5) | 5.9 (3.18) |
|
| ||
| Discontinued, No. (%) | 121 (100) | 21 (60) |
|
| ||
| Reason for discontinuation, No. (%) | ||
| Adverse reaction | 3 (3) | 0 (0) |
| Treatment failure (skeletal-related event) | 1 (1) | 0 (0) |
| Dosing interval change | 13 (11) | 2 (10) |
| Changed to pamidronate | 7 (6) | 1 (5) |
| Death | 25 (21) | 0 (0) |
| Patient/physician choice | 12 (10) | 3 (14.3) |
| Unknown | 61 (50) | 16 (76) |
