Extended Data Figure 3. Nucleotide mutation frequencies.

a) The distribution of nucleotide mutations in sequences encoding IgM are shown. On the right, the number of unmutated sequences containing no mutations in the variable gene segment is also plotted. b) The distribution of nucleotide mutations in sequences encoding IgG are shown. On the right, the mean mutation frequency for the IgG population of each subject is shown. Each line represents a single subject. For legibility, the legend is split between the two plots. Although only five subjects are shown in the legend of each plot, data from all ten subjects is present in each plot.