Table 1. Abbreviated list of GSEA categories for proteins enriched in SEVs and LEVs.

Some of the top gene sets for upregulated proteins in SEVs and in LEVs. For each gene set, the gene ontology (GO) name, # of proteins, normalized enrichment score, and false discovery rate (FDR) q value are listed.

GO Name	# proteins	Normalized Enrichment Score	FDR q value
GO Upregulated in SEVs
GO Multi Organism Membrane Organization	18	2.091002	0
GO Multi Organism Membrane Budding	16	2.0209222	3.25E-04
GO Multivesicular Body Organization	19	2.0184302	2.44E-04
GO Endosome Organization	26	1.9933468	2.74E-04
GO Cell Junction Organization	49	1.9155988	4.10E-04
GO Extracellular Structure Organization	45	1.8950502	5.96E-04
GO Cell Junction Assembly	36	1.8805888	0.001056492
GO Regulation of Vesicle Mediated Transport	69	1.8767959	0.001003668
GO Cell Matrix Adhesion	23	1.8749791	9.56E-04
GO Cell Substrate Adhesion	31	1.819944	0.002413904
GO Cell Cell Adhesion	65	1.7905699	0.00444845
GO Regulation of Epithelial Cell Migration	23	1.789166	0.004487467
GO Movement in Host Environment	23	1.7880955	0.004318077
GO Cell Cell Signaling	46	1.7619483	0.007418346
GO Positive Regulation of Secretion	30	1.7545458	0.008125004
GO Upregulated in LEVs
GO Nuclear Transcribed mRNA Catabolic Process Nonsense Mediated Decay	47	−3.415154	0
GO Ribosome Biogenesis	64	−3.395158	0
GO rRNA Metabolic Process	56	−3.3872197	0
GO Translational Initiation	68	−3.381736	0
GO Multi Organism Metabolic Process	52	−3.27132	0
GO ncRNA Processing	70	−3.0250304	0
GO Ribonucleoprotein Complex Biogenesis	97	−2.8909724	0
GO Carboxylic Acid Catabolic Process	27	−2.8225589	0
GO RNA Catabolic Process	65	−2.8172946	0
GO Protein Localization to Endoplasmic Reticulum	51	−2.8149292	0
GO Generation of Precursor Metabolites and Energy	46	−2.7052698	0
GO ncRNA Metabolic Process	97	−2.5512993	7.90E-05
GO Protein Targeting to Membrane	51	−2.2677689	9.73E-04
GO mRNA Processing	77	−2.0591824	0.008367863