Table 3. Associations between cannabis initiation polygenic scores and cannabis use trajectories.

The most significant PRS is reported, which was defined with a p-value threshold of p_T < 0.1 (see Table 2 for results for all thresholds). Results in bold are significant predictors in the model after multiple testing corrections (α < 0.0019).

	Moderate vs. No-Low			High vs. No-Low			High vs. Moderate
	Beta	SE	p	Beta	SE	p	Beta	SE	p
Cannabis Use PRS	−0.055	0.121	0.651	0.339	0.109	0.0018	0.396	0.145	0.006
Sex	1.117	0.222	5.03e-07	1.037	0.194	9.79e-08	0.015	0.258	0.955
Age at Baseline	−0.046	0.065	0.482	0.140	0.057	0.014	0.207	0.078	0.008
Age at Last Assessment	0.101	0.050	0.042	−0.116	0.043	0.007	−0.225	0.064	4.12e-04
Principal component 1	−276.537	124.649	0.027	−224.026	129.429	0.083	−51.340	219.127	0.815
Principal component 2	−81.749	82.385	0.321	101.019	101.375	0.319	69.935	168.781	0.679
Principal component 3	−29.864	49.378	0.545	7.594	48.627	0.876	38.246	70.134	0.586
Array design 1	−0.043	0.260	0.869	−0.505	0.228	0.027	−0.312	0.279	0.265
Array design 2	−0.268	0.633	0.672	−0.437	0.518	0.399	−0.089	0.713	0.900

Note: Array 1 and Array 2 are two dummy-coded variables included in the model to control for the genotyping arrays. Principal components reflect genetic ancestry.