Table 4. Associations between cannabis initiation polygenic score and perceived peer cannabis use.

The PRS that was most strongly associated with cannabis use trajectories is reported (p_T < 0.1; see Table 2). Results in bold are significant predictors in the model (α < 0.05).

	None vs. A few			None vs. Most/All			A few vs. Most/All
	Beta	SE	p	Beta	SE	p	Beta	SE	p
Cannabis Use PRS	0.021	0.083	0.799	0.324	0.129	0.012	0.184	0.111	0.096
Sex	0.419	0.145	0.004	0.528	0.222	0.018	0.073	0.201	0.717
Age at Baseline	0.099	0.045	0.026	0.315	0.072	<0.001	0.134	0.061	0.028
Age at Last Assessment	−0.021	0.033	0.529	−0.124	0.052	0.018	−0.055	0.044	0.212
Principal component 1	−380.544	255.575	0.137	−407.265	95.435	<0.001	116.519	309.088	0.706
Principal component 2	−53.450	135.154	0.692	−261.639	125.320	0.037	−309.740	188.027	0.099
Principal component 3	5.692	52.102	0.913	93.302	63.840	0.144	82.689	67.168	0.218
Array design 1	0.365	0.181	0.043	−0.416	0.269	0.122	−0.631	0.226	0.005
Array design 2	0.402	0.382	0.292	−0.846	0.672	0.208	−0.715	0.582	0.219

Note: Array 1 and Array 2 are two dummy-coded variables included in the model to control for the genotyping array types. Principal components reflect genetic ancestry.