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Cancer-associated fibroblasts enhance the frequency of ALDH+ PDAC CSCs. A, ALDH expression by Capan-1 cells following 7 days of co-culture with CAFs. Cells treated with DEAB were used as negative control for ALDH staining. Data represent the mean and SD of 3 experiments. *P < 0.05, *** P < 0.0001. B, The frequency of ALDH+ cells was analyzed in patient-derived low passage PDX (102) following co-culture with CAF35.
