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. Author manuscript; available in PMC: 2020 Apr 1.

Published in final edited form as: Am J Dermatopathol. 2019 Apr;41(4):264–272. doi: 10.1097/DAD.0000000000001259

Compound melanocytic neoplasm with severe architectural and cytological atypia. This indeterminate case was found to harbor a -124C>T TERT promoter mutation. A. A compound melanocytic neoplasm fills and expands the papillary dermis forming a domed shaped lesion (hematoxylin and eosin; 31x). B. The junctional component of the tumor has discrete nesting of melanocytes without confluence or pagetoid spread of cells (hematoxylin and eosin; 200x). C. Areas within the dermal component have expansive groupings of epithelioid melanocytes with vesicular chromatin patterns and prominent nucleoli, and there are lymphocytes present (hematoxylin and eosin; 200x). D. Mitotic figures (arrow) were rarely found in the dermal component of the melanocytic tumor (hematoxylin and eosin; 400x).

Compound melanocytic neoplasm with severe architectural and cytological atypia. This indeterminate case was found to harbor a -124C>T TERT promoter mutation. A. A compound melanocytic neoplasm fills and expands the papillary dermis forming a domed shaped lesion (hematoxylin and eosin; 31x). B. The junctional component of the tumor has discrete nesting of melanocytes without confluence or pagetoid spread of cells (hematoxylin and eosin; 200x). C. Areas within the dermal component have expansive groupings of epithelioid melanocytes with vesicular chromatin patterns and prominent nucleoli, and there are lymphocytes present (hematoxylin and eosin; 200x). D. Mitotic figures (arrow) were rarely found in the dermal component of the melanocytic tumor (hematoxylin and eosin; 400x).